Erlotinib (Tarceva) as a Single Agent or Intercalated With Combination Chemotherapy in Patients With EGFR Positive NSCLC
Completed · Phase 2
Conditions studied: Carcinoma, Non-Small-Cell Lung
In brief
This will be the first prospective study where patients will be selected on the basis of two measures of the epidermal growth factor receptor (EGFR) pathway. The study will assess prospectively the efficacy of erlotinib as a single agent or intercalated with chemotherapy in highly selected patients with EGFR overexpression and/or EGFR amplification.
Key facts
- Study ID
- NCT00294762
- Run by
- OSI Pharmaceuticals
- People needed
- 143
- Starts
- 2006-01-01
- Expected to finish
- 2009-03-01
- Last updated by the study team
- 2012-08-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age >= 18
- Histologically or cytologically documented non-small cell lung cancer (NSCLC)
- Eastern Cooperative Oncology Group (ECOG)performance status (PS)0, 1, 2
- Radiologically measurable or evaluable disease No prior chemotherapy
- 1 or 2 epithelial growth factor receptor (EGFR) pathway markers positive at screening
- Tumor tissue block or fine needle aspirate
You may not qualify if…
- Any concurrent anticancer therapy or radiation
- Other active malignancy
- Uncontrolled brain metastases
- GI abnormalities
- Severe abnormalities of the cornea
- Significant cardiac disease
- Active infection
Where it is running
- Central Hematology Oncology Medical Group Inc. — Alhambra, California, United States
- Comprehensive Blood and Cancer Center(Part of TORI network) — Bakersfield, California, United States
- Bay Area Cancer Research Group — Concord, California, United States
- Virginia K. Crosson Cancer Center — Fullerton, California, United States
- Pacific Shores Medical Group — Long Beach, California, United States
- UCLA Medical Center — Los Angeles, California, United States
- North Valley Hematology/Oncology Medical GroupThe Thomas and Dorothy Leavey Cancer Center — Northridge, California, United States
- Ventura County Hematology-Oncology Specialists — Oxnard, California, United States
- Wilshire Oncology Medical GroupThe Robert and Beverly Lewis Family Cancer Care Center — Pomona, California, United States
- Cancer Care Associates Medical Group, Inc. — Redondo Beach, California, United States
- Sansum Santa Barbara Medical Foundation Clinic — Santa Barbara, California, United States
- Santa Barbara Hematology Oncology Medical Group, Inc. — Santa Barbara, California, United States
- University of Colorado Cancer Center — Aurora, Colorado, United States
- Rocky Mountain Cancer CenterResearch Department — Denver, Colorado, United States
- Eastern Connecticut Hematology and Oncology Associates — Norwich, Connecticut, United States
- MD Anderson Cancer Ctr - Orlando — Orlando, Florida, United States
- Gulfcoast Oncology Associates — Tampa, Florida, United States
- Suburban Hematology-Oncology Associates — Lawrenceville, Georgia, United States
- Central Georgia Cancer Care, P.C. — Macon, Georgia, United States
- Rush-Presbyterian-St.Luke's Med Ctr — Chicago, Illinois, United States
- University of Chicago Medical Center — Chicago, Illinois, United States
- Norton Healthcare, Inc. — Louisville, Kentucky, United States
- Karmanos Cancer Institute — Detroit, Michigan, United States
- Univ. of Minnesota Cancer Center — Minneapolis, Minnesota, United States
- Hematology Oncology Centers of Northern Rockies Research — Billings, Montana, United States
Full record on ClinicalTrials.gov
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