The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)

Completed · Phase 4 · Has a placebo group

Conditions studied: Memory Loss

In brief

To investigate the efficacy and safety of donepezil in individuals with mild cognitive impairment on measures of cognition, global function and behavior.

Key facts

Study ID

NCT00293176

Run by

Eisai Inc.

People needed

821

Starts

2003-12-01

Expected to finish

2007-03-01

Last updated by the study team

2011-04-01

Who can join

Age: 45 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Memory complaint
• Mini Mental Status Exam (MMSE) score 24-28 inclusive
• General cognition and function performance sufficiently preserved such that a diagnosis of Alzheimer's disease (AD) cannot be made
• Generally healthy and ambulatory
• Sufficiently fluent in English

You may not qualify if…

• Diagnosis of probable or possible AD
• Neurological disorders
• History of malignant cancers
• Previously have taken donepezil or other acetylcholinesterase (ChE) inhibitors for more than 1 month or in the past 3 months prior to study entry

Where it is running

• Study site — Mesa, Arizona, United States
• Study site — Peoria, Arizona, United States
• Study site — Sun City, Arizona, United States
• Study site — Tucson, Arizona, United States
• Study site — Fresno, California, United States
• Study site — Garden Grove, California, United States
• Study site — Irvine, California, United States
• Study site — San Francisco, California, United States
• Study site — Denver, Colorado, United States
• Study site — New Haven, Connecticut, United States
• Study site — Boynton Beach, Florida, United States
• Study site — Fort Meyers, Florida, United States
• Study site — Hollywood, Florida, United States
• Study site — Jacksonville, Florida, United States
• Study site — Melbourne, Florida, United States
• Study site — North Miami, Florida, United States
• Study site — Ocala, Florida, United States
• Study site — Sarasota, Florida, United States
• Study site — St. Petersburg, Florida, United States
• Study site — Tampa, Florida, United States
• Study site — Venice, Florida, United States
• Study site — West Palm Beach, Florida, United States
• Study site — Snellville, Georgia, United States
• Study site — Chicago, Illinois, United States
• Study site — Albaster, Alabama, United States

Full record on ClinicalTrials.gov

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