Cetuximab, Cisplatin, and Radiotherapy in Women With Locally Advanced Cervical Carcinoma

Status unconfirmed · Phase 2

Conditions studied: Cancer of the Cervix

In brief

The anti-tumor activity of cetuximab prior to chemoradiotherapy and the safety and tolerability of cetuximab with concurrent chemoradiation will be determined in women with locally advanced or metastatic cervical carcinoma.

Key facts

Study ID

NCT00292955

Run by

University of Virginia

People needed

30

Starts

2006-02-01

Last updated by the study team

2011-05-30

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have signed a Washington University, Human Studies Committee (HSC) approved, informed consent.
• Patients must have primary, histologically documented FIGO Clinical Stage IB2-IVB invasive carcinoma of the uterine cervix with measurable disease amendable to repeated biopsy.
• Patients must have an ECOG performance status of 0, 1, or 2 at study entry.
• Patients, 18 years and older, must either be not of child bearing potential or have a negative pregnancy test within 7 days of treatment. Patients are considered not of child bearing potential if they are surgically sterile (they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal. Women should not breast feed while on this study.
• Women must have a primary diagnosis of invasive carcinoma of the uterine cervix. Men are excluded from this study as a consequence of the diagnosis being investigated.
• Patients must have had no previous treatment for invasive carcinoma of the uterine cervix.
• Patients must be newly diagnosed with locally advanced or metastatic cervical carcinoma.
• Bone marrow function: absolute neutrophil count (ANC) ≥ 1,500/mcl; platelets > 100,000/mcl.
• Renal function: creatinine ≤ 2.0 mg/dl.
• Hepatic function: bilirubin ≤ 1.5 times upper limit normal (ULN); SGOT ≤ 2.5 times upper limit normal (ULN).
• Patients with ureteral obstruction must be treated with stent or nephrostomy tube placement.
• Patients with neuropathy (sensory and motor) must be ≤ grade 1 defined by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 (June 10, 2003).

You may not qualify if…

• Acute hepatitis or known HIV.
• Active or uncontrolled infection.
• Significant history of uncontrolled cardiac disease i.e., uncontrolled hypertension, unstable angina, recent myocardial infarction (within prior 6 months), uncontrolled congestive heart failure, and cardiomyopathy with decreased ejection fraction.
• Prior therapy which specifically and directly targets the EGFR pathway.
• Prior severe infusion reaction to a monoclonal antibody.
• Any concurrent chemotherapy not indicated in the study protocol or any other investigational agent(s).
• A serious uncontrolled medical disorder that in the opinion of the Investigator would impair the ability of the subject to receive protocol therapy.
• Unresolved ureteral obstruction.
• Renal abnormalities, such as pelvic kidney, horseshoe kidney, or renal transplant, that would require modification of radiation fields.
• Known or documented brain metastases.
• Any concurrent malignancy other than non-melanoma skin cancer. (Patients with a previous malignancy but without evidence of disease for ≥ 5 years will be allowed to enter the trial).
• Prior radiation therapy to the abdomen and/or pelvis
• Incarceration

Where it is running

• University of Virginia Cancer Center — Charlottesville, Virginia, United States (enrolling)
• Washinton University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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