The Effect of Positive Airway Pressure on Heart Rate Variability

Completed

Conditions studied: Obstructive Sleep Apnea

In brief

This study is designed to determine the effect of continuous positive airway pressure (CPAP) or bi-level positive airway pressure (BiPAP) on heart rate variability (HRV) in patients with obstructive sleep apnea (OSA).

Key facts

Study ID

NCT00289666

Run by

Christiana Care Health Services

People needed

38

Starts

2003-07-01

Expected to finish

2008-09-01

Last updated by the study team

2016-07-11

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals aged 18-75 years old.
• Individuals with diagnosed OSA.

You may not qualify if…

• 1. Individuals who are receiving treatment for OSA, excluding those being treated by weight loss.
• Individuals who have had pharyngeal surgery (i.e., uvulopalatopharyngoplasty).
• Individuals who have arterial oxygen desaturation episodes or apneic episodes not felt to be due to OSA.
• Individuals whose treatment dosage changes 2 months prior to, or during, the study for antihypertensive and antidiabetic medications and the following medications that may affect the autonomic nervous system: anti-tuberculosis drugs, nitrofurantoin, metronidazole, chloramphenicol, perhexiline maleate, cordarone, clofibrate, tricyclic antidepressants, phenytoin, barbiturates, neuroleptic drugs, antiparkinsonism drugs, and nitrated drugs.

Where it is running

• Christiana Care Health Service — Newark, Delaware, United States

Full record on ClinicalTrials.gov

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