Melatonin Effects on Luteinizing Hormone

Stopped early · Phase 1/Phase 2

Conditions studied: Hot Flashes

In brief

In many mammals, the duration of the nocturnal melatonin elevation regulates seasonal changes in reproductive hormones such as luteinizing hormone (LH). Melatonin's effects on human reproductive endocrinology are uncertain. It is thought that the same hypothalamic pulse generator may both trigger the pulsatile release of GnRH and LH and also cause hot flashes. Thus, if melatonin suppressed this pulse generator in postmenopausal women, it might moderate hot flashes. This clinical trial tested the hypothesis that melatonin could suppress LH and relieve hot flashes.

Key facts

Study ID

NCT00288262

Run by

Scripps Health

People needed

20

Starts

2004-06-01

Expected to finish

2005-02-01

Last updated by the study team

2006-02-07

Who can join

Age: 50 and older, up to 70. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Postmenopausal woman
• Troubled by hot flashes

You may not qualify if…

• Use of reproductive hormones other than continuous estrogen or progesterone hormone replacement
• Any acute illness
• Any anticipated changes of medication
• Anemia (hemoglobin <12) or poor veins Recent trans-time-zone jet travel, shift work, or irregular sleep habits Any neurological or pituitary disease

Where it is running

• Scripps Clinic Sleep Center — La Jolla, California, United States

Full record on ClinicalTrials.gov

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