Primary Prevention of Hypertension in Obese Adolescents

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity, Pre-Hypertension, Hyperuricemia

In brief

The purpose of this study is to examine the consequences of lowering serum uric acid in pre-hypertensive, obese adolescents pathways involved with how uric acid mediated hypertension and renal disease. The specific aims are: 1. Test the hypothesis that lowering uric acid will improve endothelial function. 2. Test the hypothesis that lowering uric acid will reduce plasma renin activity and serum angiotensin II levels. 3. Test the hypothesis that lowering uric acid will reduce markers of inflammation

Key facts

Study ID

NCT00288158

Run by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

People needed

60

Starts

2008-09-01

Expected to finish

2011-01-01

Last updated by the study team

2017-09-14

Who can join

Age: 11 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children between the ages of 11 and 18
• body mass index greater than the 95th percentile for age
• Blood pressure between 75th and 95th percentile for age, gender and height percentile

You may not qualify if…

• hypertension at the time of screening
• allergy to one of the study medications
• liver function abnormality (AST or ALT greater than twice the upper limit of
• normal for the laboratory)
• history of renal stones
• renal insufficiency (Schwartz formula calculated GFR less than 70ml per min per 1.73m2 BSA)
• positive urine pregnancy test
• diabetes
• organ transplant recipient
• currently treated with an angiotensin converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), diuretic, other medications known to alter serum uric acid level
• lack of ability to comply with the study protocol

Where it is running

• Texas Children's Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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