Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
Recruiting now
Conditions studied: Barrett's Esophagus, Esophageal Neoplasm
In brief
The overall objectives of this BETRNet Research Center (RC) are: 1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA) 2. to increase the biological understanding of key observations made by our clinical researchers; 3. to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the outcomes of EAC; 4. to foster a transdisciplinary and translation research culture and to effectively expand and enhance scientific research focused on BE and EAC; 5. to evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratorydiscoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.
Key facts
- Study ID
- NCT00288119
- Run by
- Case Western Reserve University
- People needed
- 2000
- Starts
- 2005-10-01
- Expected to finish
- 2028-07-31
- Last updated by the study team
- 2026-08-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- Johns Hopkins Hospital — Baltimore, Maryland, United States (enrolling)
- Mayo Clinic — Rochester, Minnesota, United States (enrolling)
- Washington University School of Medicine — St Louis, Missouri, United States (enrolling)
- Columbia University Medical Center — New York, New York, United States (enrolling)
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States (enrolling)
- University Hospitals of Cleveland — Cleveland, Ohio, United States (enrolling)
- Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
- VA Puget Sound Health Care System — Seattle, Washington, United States (enrolling)
- Fred Hutchinson Cancer Research Center, UWMC — Seattle, Washington, United States (enrolling)
Full record on ClinicalTrials.gov
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