Hormone Therapy and Radiation Therapy or Hormone Therapy and Radiation Therapy Followed by Docetaxel and Prednisone in Treating Patients With Localized Prostate Cancer
Completed · Phase 3
Conditions studied: Prostate Cancer
In brief
RATIONALE: Androgens can cause the growth of prostate cancer cells. Hormone therapy using drugs, such as leuprolide, goserelin, flutamide, or bicalutamide, may fight prostate cancer by lowering the amount of androgens the body makes. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as docetaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving hormone therapy and radiation therapy together with chemotherapy is more effective than giving hormone therapy together with radiation therapy in treating prostate cancer. PURPOSE: This randomized phase III trial is studying hormone therapy and radiation therapy followed by docetaxel and prednisone to see how well it works compared to hormone therapy and radiation therapy in treating patients with localized prostate cancer.
Key facts
- Study ID
- NCT00288080
- Run by
- Radiation Therapy Oncology Group
- People needed
- 612
- Starts
- 2005-12-01
- Expected to finish
- 2022-05-20
- Last updated by the study team
- 2022-06-21
Who can join
Age: 18 and older, up to 120. Sex: male. Healthy volunteers: not accepted.
Where it is running
- Providence Cancer Center — Anchorage, Alaska, United States
- Arizona Oncology Services Foundation — Phoenix, Arizona, United States
- Arizona Oncology - Tucson — Tucson, Arizona, United States
- Auburn Radiation Oncology — Auburn, California, United States
- Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
- Radiation Oncology Centers - Cameron Park — Cameron Park, California, United States
- Mercy Cancer Center at Mercy San Juan Medical Center — Carmichael, California, United States
- Enloe Cancer Center at Enloe Medical Center — Chico, California, United States
- Cancer Care Center at John Muir Health - Concord Campus — Concord, California, United States
- Washington Township Hospital — Fremont, California, United States
- Sierra Nevada Cancer Center at Sierra Nevada Memorial Hospital — Grass Valley, California, United States
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- Memorial Medical Center — Modesto, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center — Rancho Mirage, California, United States
- Radiation Oncology Center - Roseville — Roseville, California, United States
- Radiological Associates of Sacramento Medical Group, Incorporated — Sacramento, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- Mercy General Hospital — Sacramento, California, United States
- California Pacific Medical Center - California Campus — San Francisco, California, United States
- Torrance Memorial Medical Center — Torrance, California, United States
- Solano Radiation Oncology Center — Vacaville, California, United States
- John Muir/Mt. Diablo Comprehensive Cancer Center — Walnut Creek, California, United States
- Rocky Mountain Cancer Centers - Aurora — Aurora, Colorado, United States
- UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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