Bone Mineral Density, Body Composition and Growth Following Severe Burn Injury

Stopped early · Phase 1

Conditions studied: Burn, Growth, Malnutrition

In brief

The purpose of this study is two-fold. The first is to establish that bone mineral density is diminished among children admitted to this regional burn center as compared to healthy non-burned children. The second purpose of this study is to examine the short and long-term effects of calcium and vitamin D supplementation in on bone metabolism and accrual in children who have been burned. Specific Aims: 1) To measure bone mineral content and bone mineral density and their change during growth in convalescent burned children admitted to a regional burn center and to compare them to normal, healthy children.; 2) To measure lean body mass, fat mass, total body water in convalescent burned children admitted to a regional burn center and compare them to normal, healthy children with focus on how these components of body composition relate to indices of bone mineral content and density; 3) To identify alterations in bone metabolism and calcium and vitamin D homeostasis following burn injury and relate these to bone mineral density in burned children; 4) To test the effect of short term calcium and vitamin D supplementation on improving bone mineral density, bone mineral content, and indices of calcium and vitamin D metabolism in acutely burned children.

Key facts

Study ID
NCT00285090
Run by
Kathy Prelack, PhD, RD
People needed
60
Starts
2005-02-01
Expected to finish
2007-02-01
Last updated by the study team
2011-12-20

Who can join

Age: 4 and older, up to 18. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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