Alteplase for Percutaneous Treatment of Loculated Abdominopelvic Abscesses

Completed · Phase 2

Conditions studied: Abdominal Abscess, Pelvic Abscess

In brief

Intracavitary injection of low dose alteplase into loculated abdominopelvic abscesses will reduce the duration of percutaneous drainage and increase the proportion of successful drainages.

Key facts

Study ID

NCT00284739

Run by

Kaiser Permanente

People needed

20

Starts

2006-02-01

Expected to finish

2007-10-01

Last updated by the study team

2015-02-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to provide written informed consent and comply with study assessments for the full duration of the study.
• Age > 18 years
• Adult, non-gravid patients with loculated abdominopelvic abscesses immediately after percutaneous drainage will be eligible to participate. A loculated abscess is defined as an abscess whose contents cannot be completely drained at the time of initial catheter placement as documented on CT.

You may not qualify if…

• Active internal bleeding, involving intracranial and retroperitoneal sites, or the gastrointestinal, genitourinary, or respiratory tracts
• History of stroke within 6 months
• Uncorrectable bleeding diathesis (INR > 1.3 despite therapy)
• Recent intracranial or intraspinal surgery or trauma
• Pregnancy (positive pregnancy test)
• Pancreatic abscesses
• Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated
• Participation in another simultaneous medical investigation or trial
• Participation in another clinical investigation within previous 30 days of catheter placement
• Prior enrollment in the study
• Known allergy to Alteplase or any of its components

Where it is running

• Kaiser Foundation Hospital — Honolulu, Hawaii, United States

Full record on ClinicalTrials.gov

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