Heparin Antibodies in Intensive Care Unit Patients (HAICU)

Completed

Conditions studied: Heparin-Induced Thrombocytopenia

In brief

Intensive care unit patients have multiple risk factors for venous thromboembolism. Venous thromboembolism leads to significant morbidity and can be fatal. Unfractionated heparin and low molecular weight heparin are commonly used to prevent venous thromboembolism. Heparin induced thrombocytopenia, an untoward consequence of exposure to heparin, is an immune disorder that may develop in patients treated with heparin products. Determining the prevalence of heparin induced thrombocytopenia and its relationship to preventive and therapeutic heparin and low molecular weight heparin will help clinicians more appropriately choose methods of venous thromboembolism prophylaxis and treatment in the critically ill, ICU population. The objective of this study is to determine the prevalence of heparin-induced antibodies on admission to the ICU and the development of new heparin-antibodies during the first week of hospitalization.

Key facts

Study ID

NCT00283322

Run by

The University of Texas Health Science Center, Houston

People needed

185

Starts

2004-11-01

Expected to finish

2006-05-01

Last updated by the study team

2007-12-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (> 18 years of age) admitted to the
• Neuro-trauma intensive care unit (NTICU)
• Shock-trauma intensive care unit (STICU) or
• Medical intensive care unit (MICU).
• Completed informed consent process.

You may not qualify if…

• Admitted to ICU for short-term observation or expected hospital length of stay of less than 5 days
• Undergoing or planned plasmaphoresis

Where it is running

• Florida Hospital Center for Hemostasis & Thrombosis (Laboratory) — Orlando, Florida, United States
• UT-Houston/Memorial Hermann Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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