Glucose Regulation in Acute Stroke Patients (GRASP) Study

Completed · Phase 2

Conditions studied: Stroke, Hyperglycemia

In brief

The purpose of this study is to assess the feasibility, safety and preliminary efficacy of the use of insulin infusions as treatment for hyperglycemic acute ischemic stroke patients.

Key facts

Study ID: NCT00282867
Run by: University of Virginia
People needed: 74
Starts: 2006-05-01
Expected to finish: 2009-02-01
Last updated by the study team: 2009-08-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

18 years of age or older.
Clinical diagnosis of ischemic stroke defined as acute neurological deficit occurring in one or more major vessels.
Must arrive at hospital and be able to begin treatment within 2 hours of established eligibility and this must be within 24 hours of symptom onset. - - Patients unable to report symptom onset time or those awakening with symptoms must use the time last known to be well as the onset time.
Admission plasma glucose of > 110 mg/dL.

You may not qualify if…

Renal dysfunction as defined by a serum creatinine of >/=2.5 mg/dL at enrollment.
Substantial pre-existing neurological or psychiatric illness that would confound neurological assessment.
Patients who have received experimental therapy for the enrollment stroke.
Pregnant females.
Patients with other severe life threatening conditions that makes them unlikely to survive 90 days.
Patients who are unable to follow the protocol or come back for 90-day followup.
Patient has condition for which insulin infusion is the usual practice or the treating physician feels that there is an indication for insulin infusion.

Where it is running

Medical College of Georgia — Augusta, Georgia, United States
University of Virginia — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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