Treatment of Rhinitis With Intranasal Vitamin E

Stopped early · Not applicable · Has a placebo group

Conditions studied: Rhinitis

In brief

Many beneficial effects of vitamin E have been described, but vitamin E supplementation by mouth has not been effective in the treatment of nasal symptoms and allergic rhinitis. The investigators will evaluate the effect of vitamin E directly applied to the lining of the nose in individuals with moderate to severe rhinitis by symptom questionnaires.

Key facts

Study ID

NCT00281307

Run by

Milton S. Hershey Medical Center

People needed

10

Starts

2005-12-07

Expected to finish

2007-09-01

Last updated by the study team

2017-07-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical symptoms of rhinitis and symptom severity score of 25 or higher on the self-administered Rhinosinusitis Questionnaire (range of 0, i.e. absence of any symptom, to 50, which indicates the most severe symptom in each category)

You may not qualify if…

• Inability to give informed consent, comprehend questions or instructions and complete questionnaires
• Recent change (within 2 weeks) in the medications that may affect nasal or sinus symptoms (intranasal or systemic glucocorticosteroids, mast cell stabilizer, antihistamines, decongestants, leukotriene antagonist, antibiotics, preparations containing thyroid or sex hormones, alpha-blocking agents)
• Intranasal use of oil- or gel-based products

Where it is running

• Cathy Mende, CRNP — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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