Changes in Cytokine Levels During an Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Completed

Conditions studied: Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive

In brief

The purpose of this study is to determine whether there is a statistical association between changes in sputum serial levels of two cytokines, interleukin (IL)-17 and IL-6, during the treatment course of a severe acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and during the clinical course itself (i.e., rate of recovery or potential complicated course). AE-COPD is defined as an episode requiring emergency room (ER) evaluation.

Key facts

Study ID

NCT00281242

Run by

University of Michigan

People needed

37

Starts

2005-09-01

Expected to finish

2010-07-01

Last updated by the study team

2016-01-29

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of COPD (following American Thoracic Society guidelines) and/or chronic bronchitis
• ER visit and/or hospitalization with AE-COPD
• Current or former smokers with more than 20 pack-years
• Willingness to participate in follow-up studies defined in the protocol
• Ability to give informed consent

You may not qualify if…

• Unstable cardiovascular disease
• Other systemic disease in which survival of more than 2 years is unlikely
• Mental incompetence or active psychiatric illness
• Currently taking more than 20 mg/day of Prednisone
• Participation in another experimental protocol within 6 weeks of study entry
• Asthma
• Cystic fibrosis
• Clinically significant bronchiectasis
• Lung cancer
• Other inflammatory or fibrotic lung disease

Where it is running

• University of Michigan at Ann Arbor — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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