T Lymphocyte Cells in Individuals Experiencing an Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Completed

Conditions studied: Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive

In brief

The purpose of this study is to determine whether the lungs of individuals with chronic obstructive pulmonary disease (COPD) contain resident memory T lymphocytes that can produce a combination of cytokines that induce the symptoms of an acute exacerbation of COPD (AE-COPD). Specifically, the study will determine cell-surface receptors of lung T cells in comparison with blood T cells from the same subject, and will examine anti-CD3-activated blood or lung T cells for interleukin (IL)-6 and interferon-gamma production in response to IL-18, and for IL-17A production in response to recombinant IL-23.

Key facts

Study ID

NCT00281229

Run by

University of Michigan

People needed

481

Starts

2005-09-01

Expected to finish

2015-01-01

Last updated by the study team

2019-06-17

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of COPD AND underwent lung resection for malignancy OR lung volume reduction surgery OR lung transplantation OR lung resection for nodules and masses

You may not qualify if…

• Mental incompetence or active psychiatric illness
• Currently using more than 20 mg/day of Prednisone
• Asthma as primary clinical pulmonary diagnosis
• Cystic fibrosis
• Clinically significant bronchiectasis
• Other inflammatory or fibrotic lung disease

Where it is running

• University of Michigan at Ann Arbor — Ann Arbor, Michigan, United States
• VA Ann Arbor Healthcare System — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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