Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD
Completed
Conditions studied: Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
In brief
This study group forms the normal subject control group in an experiment designed to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD) show abnormal responsiveness to bacterial and viral products. Specifically, the study will determine the dose-response characteristics of AMø for production of interleukin (IL)-6, IL-18, and IL-23 (pro-inflammatory cytokines) on stimulation by purified lipopolysaccharide, a synthetic lipopeptide (PAM3-Cys), or poly I:C. These stimuli mimic the response to Gram-negative bacteria, Gram-positive bacteria, and RNA viruses, respectively. Results of the AMø from these healthy volunteers will be compared with AMø of COPD patients and smokers (or ex-smokers) with normal pulmonary function; those samples are being obtained during clinically indicated bronchoscopies under a separate consent form.
Key facts
- Study ID
- NCT00281203
- Run by
- University of Michigan
- People needed
- 32
- Starts
- 2005-09-01
- Expected to finish
- 2010-07-01
- Last updated by the study team
- 2013-07-16
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy individuals with normal pulmonary function as defined by AmericanThoracic Society criteria (entry spirometry)
You may not qualify if…
- Unstable cardiovascular disease
- Other systemic disease in which survival of more than 2 years is unlikely
- Mental incompetence or active psychiatric illness
- Currently taking more than 20 mg/day of Prednisone
- Participation in another experimental protocol within 6 weeks of study entry
- Asthma
- Cystic fibrosis
- Clinically significant bronchiectasis
- Lung cancer
- Other inflammatory or fibrotic lung disease
Where it is running
- University of Michigan at Ann Arbor — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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