Comparison of Alveolar Macrophages in Individuals With COPD Versus Smokers With Normal Pulmonary Function

Completed

Conditions studied: Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive

In brief

The purpose of this study is to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD ) show abnormal responsiveness to bacterial and viral products, relative to smokers with normal pulmonary function. Participation in this study will be offered to patients already scheduled to undergo a bronchoscopy for clinical indications.

Key facts

Study ID

NCT00281190

Run by

University of Michigan

People needed

32

Starts

2005-09-01

Expected to finish

2014-10-01

Last updated by the study team

2014-12-16

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosis of COPD and/or chronic bronchitis (study group, following American Thoracic Society guidelines)
• Willingness to participate in follow-up studies defined in the protocol
• Ability to give informed consent
• Already undergoing clinically indicated bronchoscopy

You may not qualify if…

• Unstable cardiovascular disease
• Other systemic disease in which survival of more than 2 years is unlikely
• Mental incompetence or active psychiatric illness
• Currently taking more than 20 mg/day of Prednisone
• Participation in another experimental protocol within 6 weeks of study entry
• Asthma
• Cystic fibrosis
• Clinically significant bronchiectasis
• Lung cancer
• Other inflammatory or fibrotic lung disease

Where it is running

• University of Michigan at Ann Arbor — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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