Autoimmune Dysregulation in Pigmentary Glaucoma

Completed · Not applicable

Conditions studied: Pigmentary Glaucoma, Primary Open Angle Glaucoma, Cataract

In brief

Based on these recent observations and findings in this new animal model of pigmentary glaucoma in the DBA/2J mouse, we propose that immune system abnormalities in the anterior chamber may play a possible role in the development of pigmentary glaucoma and possibly primary open-angle glaucoma (POAG) in humans.

Key facts

Study ID

NCT00280345

Run by

University of Oklahoma

People needed

23

Starts

2006-02-01

Expected to finish

2009-05-01

Last updated by the study team

2023-12-15

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Any clinically significant uncontrolled medical condition(s) that might, in the investigators' opinion, interfere with the assessment.
• Use of corticosteroids within 3 months prior to surgery.
• Use of systemic anti-metabolites within 6 weeks prior to surgery.
• Use of any investigational drug within 4 weeks prior to surgery.
• Specific to the study eye exclusions:
• History of non-iatrogenic uveitis or active uveitis.
• Discernible congenital abnormality of the anterior chamber structures.
• Neovascular, uveitic, traumatic, or infantile glaucoma.
• Proliferative or severe non-proliferative diabetic retinopathy.

Where it is running

• Dean A. McGee Eye Institute — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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