Aortic Arch Reconstruction

Stopped early

Conditions studied: Congenital Disorders

In brief

Abnormalities of the aorta have been identified in patients who have undergone repair of coarctation of the aorta by various surgical techniques. These abnormalities are thought to contribute to ventricular hypertrophy, hypertension and exercise intolerance. Aortic arch reconstruction is performed for a variety of lesions besides simple coarctation of the aorta; these include hypoplastic left heart syndrome and its variants. In the latter group of patients extensive reconstruction is performed usually with a pulmonary homograft. We have previously shown that the neo-aortic dimensions and geometry are abnormal. The elastic properties of the neo-aorta, however, have not previously been described.

Key facts

Study ID

NCT00277940

Run by

Children's Healthcare of Atlanta

People needed

36

Last updated by the study team

2011-07-06

Who can join

Age: any, up to 6. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Single ventricle congenital heart disease 1) palliated with bi-directional Glenn procedure after having the Norwood procedure (experimental group) or 2) palliated with the bi-directional Glenn without having the Norwood procedure as stage I palliation-i.e. Tricuspid Atresia, Pulmonary Atresia (control group)
• Undergoing routine Fontan procedure

You may not qualify if…

• Semi-lunar valve insufficiency > trivial
• Residual coarctation noted on routine pre-Fontan catheterization
• Those who do not meet inclusion criteria

Where it is running

• Children's Healthcare of Atlanta — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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