Histamine Pharmacogenetics in Children With Atopic Dermatitis

Completed

Conditions studied: Dermatitis, Atopic

In brief

The primary goal of the study is to investigate the impact of a common genetic polymorphism in a histamine detoxification enzyme that may well have a common role in regulating the expression of atopic dermatitis (AD) and other related atopic diseases in children.

Key facts

Study ID

NCT00277433

Run by

Virginia Commonwealth University

People needed

751

Starts

2004-06-01

Expected to finish

2009-12-01

Last updated by the study team

2017-03-20

Who can join

Age: 1 and older, up to 5. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Caucasian, Hispanic and African American children ages 6 months to 5 years with a diagnosis of atopic dermatitis within the last 12 months will constitute the candidate pool for enrollment into the study group. The diagnosis of atopic dermatitis will be determined by the presence of at least 3 major diagnostic features (i.e., pruritis, rash,relapsing-remitting presentation, family history or atopy) in addition to at least 3 minor features (including but not limited to xerosis, elevated serum IgE, ocular involvement, food allergy). Healthy Caucasian, Hispanic and African American children within the same age range will comprise the pool for enrollment into the control group.

You may not qualify if…

• Any child with atopic dermatitis who has a documented history of asthma or bronchospasm or who is currently receiving treatment for either of these conditions will be excluded. Any control subject who has asthma or positive family history of allergy or atopic disease in a first-degree relative (biological mother, father or siblings) will also be ineligible for enrollment.

Where it is running

• Arkansas Children's Hospital — Little Rock, Arkansas, United States
• University of California at San Diego — San Diego, California, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Kosair Charities Pediatric Clinical Research Unit — Louisville, Kentucky, United States
• Wayne State University/Children's Hospital of Michigan — Detroit, Michigan, United States
• Children's Mercy Hospital — Kansas City, Missouri, United States
• Baylor College of Medicine/Texas Children's Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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