Pilot Study of Minocycline in Huntington's Disease

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Huntington Disease

In brief

This study is being conducted to assess the impact of minocycline on the progression of symptoms of HD. The study will also assess whether it is reasonable to continue with further study of minocycline in HD. We will measure the effect of minocycline on HD by measuring the change in Huntington's disease symptoms.

Key facts

Study ID

NCT00277355

Run by

Merit Cudkowicz

People needed

114

Starts

2006-04-01

Expected to finish

2008-11-01

Last updated by the study team

2013-04-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Clinical features of HD and a confirmatory family history of HD; and/or genetically confirmed HD
• Independently walking and fully self-sufficient in activities of daily living (eating, dressing, bathing)
• Able to take medication (capsules) by mouth

You may not qualify if…

• History of known hypersensitivity or intolerability to minocycline or known allergy to any tetracycline
• History of vestibular disease
• Subjects with underlying hematologic, hepatic or renal disease
• History of systemic lupus erythematosus (SLE)

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Colorado Neurological Institute — Englewood, Colorado, United States
• University of Florida — Gainesville, Florida, United States
• University of South Florida — Tampa, Florida, United States
• University of Maryland School of Medicine — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Albany Medical College — Albany, New York, United States
• Columbia University — New York, New York, United States
• University of Rochester — Rochester, New York, United States
• University of Texas Medical Branch at Galveston — Galveston, Texas, United States
• University of British Columbia — Vancouver, British Columbia, Canada

Full record on ClinicalTrials.gov

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