Aripiprazole to Reduce Cocaine Relapse

Completed · Phase 1 · Has a placebo group

Conditions studied: Cocaine-Related Disorders

In brief

Despite the many behavioral and cognitive treatment therapies that exist for cocaine addiction, individuals who complete cocaine abuse treatment are still at high risk for relapsing. Aripiprazole, a medication that is currently used to treat schizophrenia, may be useful in preventing drug relapse in individuals addicted to cocaine. This three-part study will evaluate the interaction between aripiprazole and cocaine. It will also determine the safety and effectiveness of aripiprazole in preventing drug relapse among cocaine addicts.

Key facts

Study ID

NCT00276874

Run by

Craig Rush

People needed

41

Starts

2006-01-01

Expected to finish

2012-01-01

Last updated by the study team

2017-04-06

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets DSM-IV diagnostic criteria for cocaine dependence
• Current cocaine use at study entry, as determined by a urine screen
• Body Mass Index of less than 30
• ECG results within normal limits
• If female, willing to use contraception throughout the study

You may not qualify if…

• Meets DSM-IV diagnostic criteria for dependence on any drugs other than cocaine or nicotine
• Currently seeking treatment for substance abuse
• Current or past serious illness, including impaired heart function, seizures, head trauma, or central nervous system tumors
• A family history of heart disease or seizures
• Current or past psychiatric disorder, other than substance abuse
• Pregnant

Where it is running

• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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