Combination Chemotherapy in Treating Young Patients With Langerhans Cell Histiocytosis
Completed · Not applicable
Conditions studied: Childhood Langerhans Cell Histiocytosis
In brief
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of Langerhans cell histiocytosis, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may be an effective treatment for Langerhans cell histiocytosis. PURPOSE: This randomized clinical trial is studying combination chemotherapy to see how well it works in treating young patients with Langerhans cell histiocytosis.
Key facts
- Study ID
- NCT00276757
- Run by
- Histiocyte Society
- People needed
- 376
- Starts
- 2001-04-01
- Expected to finish
- 2013-06-01
- Last updated by the study team
- 2014-01-10
Who can join
Age: any, up to 17. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Masonic Cancer Center at University of Minnesota — Minneapolis, Minnesota, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Vanderbilt Children's Hospital — Nashville, Tennessee, United States
- Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital — Houston, Texas, United States
- Hospital de Pediatria Garrahan — Buenos Aires, Buenos Aires, Argentina
- St. Anna Children's Hospital — Vienna, Austria
- Hospital for Sick Children — Toronto, Ontario, Canada
- CHR Hotel Dieu — Nantes, France
- University Medical Center Hamburg - Eppendorf — Hamburg, Germany
- Our Lady's Hospital for Sick Children Crumlin — Dublin, Ireland
- Fondazione I.R.C.C.S. Policlinico San Matteo — Pavia, Italy
- Karolinska University Hospital - Solna — Stockholm, Sweden
- Birmingham Children's Hospital — Birmingham, England, United Kingdom
- Institute of Child Health at University of Bristol — Bristol, England, United Kingdom
- Addenbrooke's Hospital — Cambridge, England, United Kingdom
- Leeds Cancer Centre at St. James's University Hospital — Leeds, England, United Kingdom
- Leicester Royal Infirmary — Leicester, England, United Kingdom
- Children's Cancer and Leukaemia Group — Leicester, England, United Kingdom
- Royal Liverpool Children's Hospital, Alder Hey — Liverpool, England, United Kingdom
- Royal London Hospital — London, England, United Kingdom
- Great Ormond Street Hospital for Children — London, England, United Kingdom
- Royal Manchester Children's Hospital — Manchester, England, United Kingdom
- Sir James Spence Institute of Child Health at Royal Victoria Infirmary — Newcastle upon Tyne, England, United Kingdom
- Queen's Medical Centre — Nottingham, England, United Kingdom
- Oxford Radcliffe Hospital — Oxford, England, United Kingdom
Full record on ClinicalTrials.gov
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