Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics

Completed · Not applicable

Conditions studied: Idiopathic Hypercalciuria, Hypokalemia Caused by Thiazide Diuretics

In brief

Kidney stone formation due to an excess of calcium in the urine is a common problem. It is treated with thiazide diuretics. These drugs often cause excessively low blood potassium levels that in turn require large doses of potassium supplements. These supplements are often large, unpleasant and easy to forget. We are trying the addition of spironolactone to these patients' medications to see if it allows them to take a lower dose of potassium.

Key facts

Study ID

NCT00276289

Run by

Indiana University

People needed

10

Starts

2006-01-01

Expected to finish

2006-06-01

Last updated by the study team

2009-12-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65
• History of idiopathic hypercalciuria (>200mg per 24 hours or a Ca/cr ratio of >140) felt to be the primary etiology of patient's kidney stones
• History of at least three kidney stone events
• On same dose of thiazide diuretic for at least three months
• On stable dose of K 60mEq or more a day to maintain serum K >3.5 or unable to tolerate an increase in K supplement with dose at least 40mEq a day

You may not qualify if…

• Use of ACE inhibitor, ACE receptor blocker or other medication known to effect serum potassium levels
• GFR <80 by MDRD equation
• Serious cardiac disease, diabetes, CKD , current or planned pregnancy or breastfeeding
• History of hypertension

Where it is running

• Indiana University Department of Medicine, Division of Nephrology — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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