The Effects of Hypercapnia, Supplemental Oxygen, and Dexamethasone on Surgical Wound Infection

Completed · Phase 3 · Has a placebo group

Conditions studied: Surgical Wound Infection, Surgery, Colon

In brief

The investigators will test the hypotheses that mild hypercapnia and supplemental oxygen reduce wound infection risk in patients undergoing colon resection. The investigators will simultaneously test the hypothesis that low-dose dexamethasone (a common treatment for postoperative nausea and vomiting) does not increase infection risk.

Key facts

Study ID

NCT00273377

Run by

The Cleveland Clinic

People needed

2000

Starts

2002-05-01

Expected to finish

2007-12-01

Last updated by the study team

2016-06-29

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Colon resection expected to last >2 and <6 hours

You may not qualify if…

• Bowel obstruction
• Fever

Where it is running

• Outcomes Research Institute — Louisville, Kentucky, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University of Vienna — Vienna, Austria
• Mater Misericordiae Hospital — Dublin, Ireland

Full record on ClinicalTrials.gov

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