Drug Compliance and Quality of Life in Patients With Heart Failure Dosed With Either Once-daily or Twice-daily Coreg

Completed · Phase 3

Conditions studied: Chronic Heart Failure

In brief

The purpose of this study is to compare dosing compliance between study patients taking controlled release carvedilol once a day, and study patients taking immediate release carvedilol (Coreg) twice a day.

Key facts

Study ID

NCT00272805

Run by

Cardiovascular Clinical Sciences Inc

People needed

400

Starts

2005-10-01

Expected to finish

2006-07-01

Last updated by the study team

2013-02-18

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to read English
• Stable symptoms of mild to severe heart failure
• Stable medical regimen for heart failure
• On a stable dose of Coreg for at least 2 months
• LVEF ≤40% within the previous 24 months

You may not qualify if…

• Uncorrected obstructive or regurgitant valve disease
• Complex congenital heart disease
• Recent ICD or pacemaker placement
• Recent coronary artery bypass surgery or stroke
• Candidate for heart transplanct within 5 months of study start
• Present or planned use of MAO inhibitors, alfpha-blockers, combined alpha-beta blockers, any Class I/II anti-arrythmnic agents, (amiodarone may be used if ≤ 200mg/day). Use of intravenous vasodilator/inotropic agents.

Where it is running

• Radiant Research — Sierra Vista, Arizona, United States
• Cardiology Consultants of Orange County — Anaheim, California, United States
• Access Clinical Trials — Beverly Hills, California, United States
• Cardiovascular Consultants Medical Group — Oakland, California, United States
• San Diego Cardiac Center — San Diego, California, United States
• Northern California Medical Associates — Santa Rosa, California, United States
• Radiant Research — Santa Rosa, California, United States
• Cardiovascular Consultants Medical Group — Walnut Creek, California, United States
• Heart Center of the Rockies — Fort Collins, Colorado, United States
• St. Francis Hospital and Medical Center — Hartford, Connecticut, United States
• NextPhase Clinical Trials — Miami, Florida, United States
• Charlotte Heart Group Research Center — Port Charlotte, Florida, United States
• The Heart and Vascular Institute of Florida — St. Petersburg, Florida, United States
• Cardiac Disease Specialists — Atlanta, Georgia, United States
• CVMS Research Institute of Augusta — Augusta, Georgia, United States
• Georgia Heart Specialists — Covington, Georgia, United States
• Idaho Cardiology Associates — Boise, Idaho, United States
• North Shore Cardiologists — Bannockburn, Illinois, United States
• Midwest Heart Foundation — Lombard, Illinois, United States
• Illinois Heart and Lung Research Center — Normal, Illinois, United States
• The Care Group — Indianapolis, Indiana, United States
• Clinical Trials Management — Metairie, Louisiana, United States
• Androscoggin Cardiology Associates-Research — Auburn, Maine, United States
• Maine Cardiology Associates — S.Portland, Maine, United States
• The Heart Group — Mobile, Alabama, United States

Full record on ClinicalTrials.gov

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