Correlation of Endothelial Function and Early Coronary Artery Disease in Humans
Completed · Phase 3
Conditions studied: Endothelial Dysfunction
In brief
Qualifying patients who are scheduled for angiogram with endothelial function testing are approached to participate in this protocol (consent form reviewed with patient). Those who are willing to participate will have additional measurements taken during their angiogram as part of this protocol. Patients who are diagnosed with Endothelial Dysfunction as a result of a clinically indicated angiogram will be eligible to participate in a 6 month medication trial (Atrasentan vs. placebo - randomized, blinded trial). Patients are monitored closely during the 6 month trial via phone calls and blood testing for assessment. At the end of the 6 months they return to Mayo for a repeat angiogram to assess endothelial function for any changes or improvements.
Key facts
- Study ID
- NCT00271492
- Run by
- Mayo Clinic
- People needed
- 200
- Starts
- 2001-07-01
- Expected to finish
- 2008-01-01
- Last updated by the study team
- 2010-04-30
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 18 years and < 85 years
- Male or female
You may not qualify if…
- Left dominant circulation
- Heart failure with EF <40%
- Unstable angina
- MI or angioplasty of the LAD or circumflex with 6 months prior to entry into the study
- Use of radiographic contrast agent within 12 hours of entry into the study
- Use of investigational agents within one month of entry into the study
- Patients who require treatment with positive inotropic agents other than digoxin during the study
- Patients with cerebrovascular accident within 6 months prior to entry into the study
- Significant endocrine, hepatic, renal disorders; local or systemic infectious disease within 4 weeks prior to entry into study
- Pregnancy or lactation
- Mental instability
- Federal Medical Center patients
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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