Blood Cell Collection for Future Use in Individuals With Fanconi Anemia

Completed · Not applicable

Conditions studied: Fanconi Anemia

In brief

Fanconi anemia (FA) is a disease that affects an individual's bone marrow. It is caused by a defective gene in the CD34+ cells, which are responsible for producing various types of blood cells. Individuals with FA may experience fatigue, bleeding, and increased infections. The purpose of this study is to collect and purify blood cells from individuals with FA and store them for future therapeutic use.

Key facts

Study ID

NCT00271089

Run by

National Heart, Lung, and Blood Institute (NHLBI)

People needed

40

Starts

2004-08-01

Expected to finish

2007-10-01

Last updated by the study team

2016-07-12

Who can join

Age: 1 and older, up to 35. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of FA
• Normal bone marrow cytogenetics within 3 months of study entry
• Absolute neutrophil count (ANC) level greater than 750
• Hemoglobin level greater than 8 without transfusion
• Platelet level greater than 30,000 without transfusion
• Must weigh at least 7.5 kg

You may not qualify if…

• Myloid or lymphoid leukemia
• Cytogenic abnormalities
• HIV infected
• Neoplastic or non-neoplastic disease of any major organ system that would compromise the ability to withstand the collection procedure
• Uncontrolled infection
• Unable to tolerate general anesthesia
• Known adverse reaction to E. Coli
• Pregnant or breastfeeding

Where it is running

• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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