SB-480848 In Subjects With Coronary Heart Disease

Completed · Phase 2 · Has a placebo group

Conditions studied: Atherosclerosis

In brief

This trial of SB-480848 in approximately 920 subjects with Coronary Heart Disease (CHD) or CHD-risk equivalent will examine whether SB-480848 produces sustained inhibition of plasma Lp-PLA2 activity, explore the effects of SB-480848 on other circulating biomarkers associated with cardiovascular risk, and evaluate the pharmacokinetics, safety and tolerability of SB-480848 over 12 weeks of once-daily oral dosing. Subjects will first be randomized 1:1 to double-blind atorvastatin 20 mg or 80 mg once daily for a minimum of 3 weeks. Subjects will then be randomized 1:1:1:1 to oral doses of SB-480848 40 mg, 80 mg, 160 mg or placebo once daily for 12 weeks. Blood samples will be collected at various timepoints. Vital signs, electrocardiograms, clinical laboratory safety tests and adverse event assessments will be performed to evaluate the safety and tolerability of SB-480848.

Key facts

Study ID

NCT00269048

Run by

GlaxoSmithKline

People needed

969

Starts

2005-11-01

Expected to finish

2006-09-01

Last updated by the study team

2016-08-08

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Female subjects must be of non-childbearing potential.
• Stable CHD or CHD-risk equivalent.
• Must have been on a stable dose of a statin for =4 weeks with LDL <130 mg/dL (3.4 mmol/L) or off statin therapy for =4 weeks with LDL <160 mg/dL (4.1 mmol/L).
• On a stable dose of at least one oral antiplatelet agent (e.g., aspirin, clopidogrel, or ticlopidine).

You may not qualify if…

• Recent cardiovascular event and / or vascular procedure.
• History of difficult to manage dyslipidemia.
• Planned cardiac surgery or PCI (percutaneous coronary intervention) or planned major non-cardiac surgery.
• Inadequately controlled hypertension.
• Poorly controlled diabetes mellitus.
• Serum triglycerides >400 mg/dL (4.52 mmol/L).
• Recent or ongoing acute infection.
• History of chronic inflammatory disease.
• Receiving topical, oral, inhaled or injectable corticosteroids.
• History of chronic viral hepatitis, or other chronic hepatic disorders.
• History of kidney transplant.
• History of myopathy or inflammatory muscle disease, or elevated total serum CK (3 x ULN).
• Severe heart failure (NYHA class III or IV), or severe left ventricular dysfunction (ejection fraction <30%).
• Asthma manifested by bronchospasm in the past 6 months, or currently taking inhaled bronchodilator on regular basis.
• History of anaphylaxis, anaphylactoid reactions or severe allergic responses within the past 6 months.
• Malignancy within the past 2 years, other than non-melanoma skin cancer.
• Current life-threatening condition other than vascular disease that may prevent a subject from completing the study.
• QTc interval >440 msec (males) or >450 msec (females).
• Alcohol or drug abuse within the past 6 months.
• Previous exposure to SB-480848.
• Use of an investigational drug within 30 days or 5 half-lives (whichever is the longer) preceding the first dose of study medication (blinded atorvastatin).

Where it is running

• GSK Investigational Site — Northport, Alabama, United States
• GSK Investigational Site — Phoenix, Arizona, United States
• GSK Investigational Site — Tucson, Arizona, United States
• GSK Investigational Site — Spring Valley, California, United States
• GSK Investigational Site — Torrance, California, United States
• GSK Investigational Site — Walnut Creek, California, United States
• GSK Investigational Site — Fort Lauderdale, Florida, United States
• GSK Investigational Site — Jacksonville, Florida, United States
• GSK Investigational Site — Pembroke Pines, Florida, United States
• GSK Investigational Site — Chicago, Illinois, United States
• GSK Investigational Site — Chicago, Illinois, United States
• GSK Investigational Site — Indianapolis, Indiana, United States
• GSK Investigational Site — Lacombe, Louisiana, United States
• GSK Investigational Site — Slidell, Louisiana, United States
• GSK Investigational Site — Auburn, Maine, United States
• GSK Investigational Site — New York, New York, United States
• GSK Investigational Site — Statesville, North Carolina, United States
• GSK Investigational Site — Cincinnati, Ohio, United States
• GSK Investigational Site — Oklahoma City, Oklahoma, United States
• GSK Investigational Site — Camp Hill, Pennsylvania, United States
• GSK Investigational Site — Philadelphia, Pennsylvania, United States
• GSK Investigational Site — Bryan, Texas, United States
• GSK Investigational Site — Houston, Texas, United States
• GSK Investigational Site — San Antonio, Texas, United States
• GSK Investigational Site — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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