Oxaliplatin and Capecitabine With or Without an Hepatic Arterial Infusion With Floxuridine in Treating Patients Who Are Undergoing Surgery and/or Ablation for Liver Metastases Due to Colorectal Cancer

Stopped early · Phase 3

Conditions studied: Colorectal Cancer, Metastatic Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, capecitabine, and floxuridine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Hepatic arterial infusion uses a catheter to carry tumor-killing substances, such as chemotherapy, directly into the liver. Giving chemotherapy in different ways may kill more tumor cells. It is not yet known whether giving oxaliplatin and capecitabine together with an hepatic arterial infusion with floxuridine is more effective than giving oxaliplatin and capecitabine alone in treating patients who are undergoing surgery and/or ablation for liver metastases due to colorectal cancer. PURPOSE: This randomized phase III trial is studying oxaliplatin, capecitabine, and an hepatic arterial infusion with floxuridine to see how well they work compared to oxaliplatin and capecitabine in treating patients who are undergoing surgery and/or ablation for liver metastases due to colorectal cancer.

Key facts

Study ID

NCT00268463

Run by

NSABP Foundation Inc

People needed

22

Starts

2006-01-01

Expected to finish

2008-06-01

Last updated by the study team

2013-05-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Cancer Care Center at John Muir Health - Concord Campus — Concord, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• Veterans Affairs Medical Center - Loma Linda (Pettis) — Loma Linda, California, United States
• Kaiser Permanente Medical Center - Walnut Creek — Walnut Creek, California, United States
• John Muir/Mt. Diablo Comprehensive Cancer Center — Walnut Creek, California, United States
• CCOP - Christiana Care Health Services — Newark, Delaware, United States
• Washington Cancer Institute at Washington Hospital Center — Washington D.C., District of Columbia, United States
• Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
• Via Christi Cancer Center at Via Christi Regional Medical Center — Wichita, Kansas, United States
• Central Baptist Hospital — Lexington, Kentucky, United States
• Louisville Oncology at Norton Cancer Center — Louisville, Kentucky, United States
• CCOP - Ochsner — New Orleans, Louisiana, United States
• Harry & Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center — Baltimore, Maryland, United States
• Saint Joseph Mercy Cancer Center — Ann Arbor, Michigan, United States
• Borgess Medical Center — Kalamazoo, Michigan, United States
• West Michigan Cancer Center — Kalamazoo, Michigan, United States
• Bronson Methodist Hospital — Kalamazoo, Michigan, United States
• Mayo Clinic Cancer Center — Rochester, Minnesota, United States
• Wake Forest University Comprehensive Cancer Center — Winston-Salem, North Carolina, United States
• Altru Cancer Center at Altru Hospital — Grand Forks, North Dakota, United States
• Natalie Warren Bryant Cancer Center at St. Francis Hospital — Tulsa, Oklahoma, United States
• Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center — Portland, Oregon, United States
• CCOP - Columbia River Oncology Program — Portland, Oregon, United States
• Providence St. Vincent Medical Center — Portland, Oregon, United States
• St. Luke's Cancer Network at St. Luke's Hospital — Bethlehem, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.