Radiation Therapy, Pemetrexed Disodium, and Carboplatin in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed By Surgery
Stopped early · Phase 2
Conditions studied: Esophageal Cancer
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as pemetrexed disodium and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Pemetrexed disodium may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving radiation therapy together with pemetrexed disodium and carboplatin before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. PURPOSE: This phase II trial is studying how well giving radiation therapy together with pemetrexed disodium and carboplatin works in treating patients with locally advanced esophageal cancer that can be removed by surgery.
Key facts
- Study ID
- NCT00268437
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 27
- Starts
- 2006-04-01
- Expected to finish
- 2015-03-01
- Last updated by the study team
- 2016-07-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Rush-Copley Cancer Care Center — Aurora, Illinois, United States
- Graham Hospital — Canton, Illinois, United States
- Memorial Hospital — Carthage, Illinois, United States
- St. Anthony's Memorial Hospital — Effingham, Illinois, United States
- Eureka Community Hospital — Eureka, Illinois, United States
- Galesburg Clinic, PC — Galesburg, Illinois, United States
- Galesburg Cottage Hospital — Galesburg, Illinois, United States
- InterCommunity Cancer Center of Western Illinois — Galesburg, Illinois, United States
- Mason District Hospital — Havana, Illinois, United States
- Hopedale Medical Complex — Hopedale, Illinois, United States
- Joliet Oncology-Hematology Associates, Limited - West — Joliet, Illinois, United States
- Kewanee Hospital — Kewanee, Illinois, United States
- McDonough District Hospital — Macomb, Illinois, United States
- BroMenn Regional Medical Center — Normal, Illinois, United States
- Community Cancer Center — Normal, Illinois, United States
- Community Hospital of Ottawa — Ottawa, Illinois, United States
- Oncology Hematology Associates of Central Illinois, PC - Ottawa — Ottawa, Illinois, United States
- Cancer Treatment Center at Pekin Hospital — Pekin, Illinois, United States
- Proctor Hospital — Peoria, Illinois, United States
- CCOP - Illinois Oncology Research Association — Peoria, Illinois, United States
- Oncology Hematology Associates of Central Illinois, PC - Peoria — Peoria, Illinois, United States
- Methodist Medical Center of Illinois — Peoria, Illinois, United States
- Illinois Valley Community Hospital — Peru, Illinois, United States
- Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
Full record on ClinicalTrials.gov
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