S0427, Combination Chemotherapy & RT in Treating Patients With Stage III or Stage IV Cancer of the Oropharynx
Stopped early · Phase 3
Conditions studied: Head and Neck Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as docetaxel, cisplatin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy together with radiation therapy may kill more tumor cells. It is not yet known whether giving combination chemotherapy together with radiation therapy is more effective than giving cisplatin together with radiation therapy in treating cancer of the oropharynx. PURPOSE: This randomized phase III trial is studying combination chemotherapy and radiation therapy to see how well they work compared to cisplatin and radiation therapy in treating patients with stage III or stage IV cancer of the oropharynx.
Key facts
- Study ID
- NCT00268372
- Run by
- SWOG Cancer Research Network
- People needed
- 6
- Starts
- 2005-12-01
- Expected to finish
- 2007-12-01
- Last updated by the study team
- 2012-10-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rush-Copley Cancer Care Center — Aurora, Illinois, United States
- John H. Stroger, Jr. Hospital of Cook County — Chicago, Illinois, United States
- Decatur Memorial Hospital Cancer Care Institute — Decatur, Illinois, United States
- Veterans Affairs Medical Center - Hines — Hines, Illinois, United States
- Joliet Oncology-Hematology Associates, Limited - West — Joliet, Illinois, United States
- Trinity Medical Center - East — Moline, Illinois, United States
- Study site — Moline, Illinois, United States
- West Suburban Center for Cancer Care — River Forest, Illinois, United States
- Regional Cancer Center at Memorial Medical Center — Springfield, Illinois, United States
- Carle Cancer Center at Carle Foundation Hospital — Urbana, Illinois, United States
- CCOP - Carle Cancer Center — Urbana, Illinois, United States
- Saint Anthony Memorial Health Centers — Michigan City, Indiana, United States
- Study site — Bettendorf, Iowa, United States
- Siouxland Hematology-Oncology Associates, LLP — Sioux City, Iowa, United States
- Siouxland Regional Cancer Center — Sioux City, Iowa, United States
- Mercy Medical Center - Sioux City — Sioux City, Iowa, United States
- St. Luke's Regional Medical Center — Sioux City, Iowa, United States
- Cancer Center of Kansas, PA - Chanute — Chanute, Kansas, United States
- Cancer Center of Kansas, PA - Dodge City — Dodge City, Kansas, United States
- Cancer Center of Kansas, PA - El Dorado — El Dorado, Kansas, United States
- Cancer Center of Kansas, PA - Kingman — Kingman, Kansas, United States
- Southwest Medical Center — Liberal, Kansas, United States
- Cancer Center of Kansas, PA - Newton — Newton, Kansas, United States
- Cancer Center of Kansas, PA - Parsons — Parsons, Kansas, United States
- Eastern Connecticut Hematology and Oncology Associates — Norwich, Connecticut, United States
Full record on ClinicalTrials.gov
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