Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
Completed · Phase 3
Conditions studied: Colorectal Cancer
In brief
PURPOSE: This randomized phase III trial is studying cetuximab and/or bevacizumab when given together with combination chemotherapy to compare how well they work in treating patients with metastatic colorectal cancer. RATIONALE: Monoclonal antibodies, such as cetuximab and bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in chemotherapy, such as fluorouracil, leucovorin, oxaliplatin, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving monoclonal antibodies together with combination chemotherapy may kill more tumor cells. It is not yet known whether combination chemotherapy is more effective with cetuximab and/or bevacizumab in treating patients with colorectal cancer.
Key facts
- Study ID
- NCT00265850
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 2334
- Starts
- 2005-11-01
- Expected to finish
- 2018-01-01
- Last updated by the study team
- 2026-08-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alaska Regional Hospital Cancer Center — Anchorage, Alaska, United States
- Providence Cancer Center — Anchorage, Alaska, United States
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith, Arkansas, United States
- NEA Medical Center - Stadium Boulevard — Jonesboro, Arkansas, United States
- Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center — Burbank, California, United States
- East Bay Radiation Oncology Center — Castro Valley, California, United States
- Valley Medical Oncology Consultants - Castro Valley — Castro Valley, California, United States
- North Bay Cancer Center — Fairfield, California, United States
- Kaiser Permanente - Fremont — Fremont, California, United States
- Valley Medical Oncology — Fremont, California, United States
- Glendale Memorial Hospital Comprehensive Cancer Center — Glendale, California, United States
- California Cancer Care, Incorporated - Greenbrae — Greenbrae, California, United States
- Kaiser Permanente Medical Center - Hayward — Hayward, California, United States
- Veterans Affairs Medical Center - Loma Linda (Pettis) — Loma Linda, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Contra Costa Regional Medical Center — Martinez, California, United States
- Tibotec Therapeutics - Division of Ortho Biotech Products, LP — Marysville, California, United States
- Camino Medical Group - Treatment Center — Mountain View, California, United States
- El Camino Hospital Cancer Center — Mountain View, California, United States
- Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
- Bay Area Breast Surgeons, Incorporated — Oakland, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Larry G Strieff MD Medical Corporation — Oakland, California, United States
- Tom K Lee, Incorporated — Oakland, California, United States
- Providence Cancer Center at Providence Hospital — Mobile, Alabama, United States
Full record on ClinicalTrials.gov
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