Treatment of Refractory Status Epilepticus

Stopped early · Phase 3

Conditions studied: Status Epilepticus

In brief

The purpose of this study is to determine whether propofol or barbiturates should be preferred in the treatment of status epilepticus (continuous seizure activity) refractory to 2 standard antiepileptic agents.

Key facts

Study ID

NCT00265616

Run by

Brigham and Women's Hospital

People needed

23

Starts

2006-05-01

Expected to finish

2010-03-01

Last updated by the study team

2013-04-09

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with refractory status epilepticus not due to cerebral anoxia, needing coma induction for clinical management.

You may not qualify if…

• Age < 16 years old.
• Known pregnancy.
• Cerebral anoxia as SE etiology.
• Epilepsia partialis continua (simple partial SE).
• Known intolerance to the study drugs.
• Known mitochondrial disorder, hyperlipidemia, or significant rhabdomyolysis.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Inselspital — Bern, Canton of Bern, Switzerland
• CHUV — Lausanne, Canton of Vaud, Switzerland
• Hôpitaux Universitaires de Genève — Geneva, Switzerland

Full record on ClinicalTrials.gov

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