An fMRI Study of the Effect of Intravenous Oxytocin vs. Placebo on Response Inhibition and Face Processing in Autism

Completed · Phase 1 · Has a placebo group

Conditions studied: Autism

In brief

To study the effect of oxytocin on face processing and response inhibition in autistic adults by fMRI.

Key facts

Study ID

NCT00263796

Run by

Anagnostou, Evdokia, M.D.

People needed

16

Starts

2006-03-01

Expected to finish

2012-09-01

Last updated by the study team

2014-04-30

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet DSM-IV, ADI, or ADOS criteria for autism spectrum disorder.
• Age 18-50.
• Be seen as outpatients
• IQ>80
• 5. Demonstrate capacity to provide authorized informed consent or provide consent for participation by an approved surrogate on the autistic individual's behalf

You may not qualify if…

• Subjects who are pregnant or nursing mothers. Sexually active women of childbearing potential who are not using adequate birth control measures.
• Subjects with epilepsy.
• Subjects with a history of schizophrenia, schizoaffective disorder or other Axis 1 mental disorders, such as bipolar disorder.
• Subjects reporting history of encephalitis, phenylketonuria, tuberous sclerosis, fragile X syndrome, anoxia during birth, neurofibromatosis, hypomelanosis, hypothyroidism, Duchenne muscular dystrophy, and maternal rubella
• Subjects who have received depot neuroleptic medication, or other psychoactive drugs within the past 5 weeks.
• Subjects with renal or liver disease or abnormalities in blood chemistry.
• Any metallic prosthesis such as plates, pins and screws, shrapnel, metallic foreign body, vascular or neurosurgical clips that may be incompatible with the MRI and any electrical devices such as a pacemaker or a defibrillator
• Claustrophobia

Where it is running

• Mount Sinai School of Medicine — New York, New York, United States

Full record on ClinicalTrials.gov

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