Safety and Efficacy of a Contraceptive Vaginal Ring Delivering Nestorone® and Ethinyl Estradiol

Completed · Phase 3

Conditions studied: Contraception

In brief

The purpose of this 1-year study is to evaluate the efficacy and safety of a new contraceptive vaginal ring (CVR) delivering low doses of Nestorone (NES), a new, nonandrogenic progestin, and ethinyl estradiol (EE), an estrogen used in oral contraceptives. The CVR, which is made of silicone rubber, is designed to be used for 1 year (13 menstrual cycles) before replacement is required.

Key facts

Study ID: NCT00263341
Run by: Population Council
People needed: 1135
Starts: 2005-12-01
Expected to finish: 2014-08-01
Last updated by the study team: 2017-10-06

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Healthy women who meet the following criteria:
Aged 18-<40 years who wish to use a combined hormonal contraceptive.
Women not intending to become pregnant for 13 months.
Intact uterus and both ovaries.
Prior history of regular menstrual cycles of 28 ± 7 days when not using hormonal contraception; if postpartum or postabortal, history of regular menstrual cycles of 21-35 days in length and at least one cycle (2 menses) with a cycle length consistent with her past cycles.
Sexually active (currently) and willing to discontinue current contraceptive method to participate in the study.
In the opinion of the investigator, able to comply with the protocol, e.g. live within the clinic catchment area or within a reasonable distance from the clinic.
Do not meet any of the exclusion criteria.
Signed informed consent prior to entry into the trial.
[For pharmacokinetics study only; 39 subjects already recruited]
Willing to undergo frequent blooding sampling

You may not qualify if…

Contraindications for enrollment will be the same as those for use with combined hormonal contraceptives in addition to contraindications specific to this clinical trial including:
Known hypersensitivity to estrogens or progestins.
Known hypersensitivity to silicone rubber.
Known or suspected pregnancy.
History of infertility of >1.0 year in woman or her male partner.
History of vasectomy or sterility in male partner; tubal ligation (sterilization) in women.
Undiagnosed abnormal genital bleeding.
Undiagnosed vaginal discharge or vaginal lesions or abnormalities. (Subjects diagnosed at screening with a chlamydia or gonococcus infection may be included in the trial following treatment; partner treatment is also recommended. Investigators should make a determination if subjects are at high risk for reinfection, e.g. multiple sex partners, untreated partner, and whether such subjects can be included.)
History of pelvic inflammatory disease since last pregnancy episode.
History of toxic shock syndrome.
Current abnormal Pap smear (women who have abnormal Paps but are ASCUS HPV negative may participate provided there is follow up for this finding per standard of care).
Cystoceles or rectoceles or other anatomical abnormality that would preclude use of a vaginal ring.
Women planning to undergo major surgery.
Smoking in women who are 35 years and over or will be 35 years during the course of the trial; women < 35yrs who smoke 15 cigarettes or more must be evaluated by the PI for inclusion based on risk factors that would increase their risk for CVD, e.g. lipid levels, glucose level, BP, BMI, family history of CVD at a young age.
Breastfeeding.
Current or past thrombophlebitis or thromboembolic disorders.
History of venous thrombosis or embolism in a first-degree relative, <55 years of age suggesting a familial defect in the blood coagulation system, which in the opinion of the PI, suggests use of a hormonal contraceptive could pose a significant risk.
Cerebrovascular or cardiovascular disease.
History of retinal vascular lesions, unexplained partial or complete loss of vision.
Known or suspected carcinoma of the breast.
Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia.
Past history of any other carcinoma unless in remission for more than 5 years.
Current or history of medically diagnosed severe depression, which, in the opinions of the investigator, could be exacerbated by use of a hormonal contraceptive.
Headaches with focal neurological symptoms.
Severe constipation.

Where it is running

Women and Children's Hospital, LAC/USC Medical Center — Los Angeles, California, United States
University of California, San Francisco General Hospital, Department of Obstetrics & Gynecology — San Francisco, California, United States
University of Chicago Hospitals — Chicago, Illinois, United States
Montefiore Medical Center/Albert Einstein College of Medicine — The Bronx, New York, United States
Columbus Center for Women's Heatlh Research — Columbus, Ohio, United States
FPA Health — Ashfield, Australia
University of Campinas, Department of Obstetrics & Gynecology — São Paulo, Brazil
Instituto Chileno de Medicina Reproductiva — Santiago, Chile
Profamilia — Santo Domingo, Dominican Republic
Family Federation of Finland — Helsinki, Finland
University of Szeged, Department of Obstetrics & Gynecology — Szeged, Hungary
Karolinska Institutet, Department of Woman and Child Health, Division of Obstetrics & Gynecology — Stockholm, Sweden

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.