Radiation Therapy and Temozolomide Followed by Temozolomide and Poly ICLC in Treating Patients With Newly Diagnosed GBM
Completed · Phase 2
Conditions studied: Glioblastoma Multiforme
In brief
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Biological therapies, such as poly ICLC, may stimulate the immune system in different ways and stop tumor cells from growing. Giving poly ICLC after radiation therapy and temozolomide may stop any remaining tumor cells from growing. PURPOSE: This phase II trial is studying how well giving radiation therapy together with temozolomide followed by temozolomide and poly ICLC works in treating patients with newly diagnosed glioblastoma multiforme.
Key facts
- Study ID
- NCT00262730
- Run by
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- People needed
- 97
- Starts
- 2006-01-01
- Expected to finish
- 2010-04-01
- Last updated by the study team
- 2019-06-12
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Lurleen Wallace Comprehensive Cancer at University of Alabama-Birmingham — Birmingham, Alabama, United States
- H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa, Florida, United States
- Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
- Massachusetts General Hospital Cancer Center — Boston, Massachusetts, United States
- Josephine Ford Cancer Center at Henry Ford Hospital — Detroit, Michigan, United States
- Wake Forest University Comprehensive Cancer Center — Winston-Salem, North Carolina, United States
- Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio, United States
- Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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