Bupropion for Hospital-Based Smoking Cessation
Completed · Phase 3 · Has a placebo group
Conditions studied: Smoking
In brief
This is a randomized blinded trial of whether hospitalized smokers who are randomly assigned to receive bupropion, an antidepressant, and cognitive-behavioral counseling, are more likely to have quit smoking at the end of treatment and at 6 months compared with smokers randomly assigned to receive placebo and cognitive-behavioral counseling. Because depression is more prevalent among smokers and because smokers who are prone to depression may become depressed when they quit, the hypothesis is that the proportion of quitters who receive the active drug/antidepressant will be greater than the proportion of quitters who receive the placebo drug at 6 months.
Key facts
- Study ID
- NCT00261170
- Run by
- University of California, San Francisco
- People needed
- 85
- Starts
- 2003-07-01
- Expected to finish
- 2007-02-01
- Last updated by the study team
- 2008-05-23
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- currently smoking - use of tobacco products during the week prior to hospital admission and having smoked at least 5 cigarettes /day during the past year
- eligibility to receive medical care in a VA hospital
- hospitalization for at least 48 hours to provide sufficient time to identify, screen, enroll and counsel participants
- willingness to participate and give informed consent
You may not qualify if…
- hospitalization for acute CHD syndromes
- contraindications to the use of bupropion
- family history of seizure disorder, history of severe head trauma, predisposition to seizures
- unstable psychiatric disorder
- pregnancy, lactation
- current alcohol (defined as greater than 3 drinks/day) or drug abuse (defined as current/within last 3 months use of narcotics, heroin, cocaine, amphetamines)
- current untreated depression (BDI score > or = 30)
- terminal illness
- inability to be contacted by phone
Where it is running
- Veterans Affairs Medical Center — San Francisco, California, United States
Full record on ClinicalTrials.gov
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