Effect of Valdecoxib Pretreatment on Pain and Secondary Hyperalgesia in Healthy Volunteers

Completed · Phase 4

Conditions studied: Pain, Hyperalgesia

In brief

Tis study was designed to test the hypothesis that pretreatment with valdecoxib, prior to injury could reduce or prevent the development of secondary hyperalgesia around the area of primary injury. A heat/capsaicin model of induced hyperalgesia was tested in healthy volunteers in a randomized, double blind, cross-over trial of a single dose of 40 mg vadecoxib versus control. Subjects rated pain intesnsity and unpleasantness following heat stimulation of the forearm, the area of hyperalgesia was also mapped over the course of the experiment.

Key facts

Study ID

NCT00260325

Run by

Penn State University

People needed

20

Starts

2004-08-01

Expected to finish

2006-04-01

Last updated by the study team

2017-11-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy male of non-pregnant female; 18yo or older
• not currently taking NSAID
• able and willing to provide informed consent
• willing to avoid other NSAIDs in 24 hour period following study
• no known hypersentitivites or contraindications to NSAIDS, sulfonomides or capsaicin

You may not qualify if…

• pregnant or breast feeding
• use of NSAIDS or other analgesic medications in past 7 days
• unwilling or unable to give informed consent
• contraindication to any study medication or other NSAID

Where it is running

• Penn State University College of Medicine — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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