High-dose Periop Statins for Prevention of DVT

Completed · Not applicable

Conditions studied: Gynecologic Oncological Pelvic/Abdominal Surgery

In brief

This study is designed to determine if the use of atorvastatin (Lipitor), a member of the HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory responses and deep vein thrombosis formation when given in high doses in the perioperative period.

Key facts

Study ID

NCT00259662

Run by

Yale University

People needed

29

Starts

2005-11-01

Expected to finish

2007-08-01

Last updated by the study team

2016-12-01

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• gynecologic tumor scheduled for resection

You may not qualify if…

• prior reaction to statins
• renal insufficiency
• liver disease
• h/o alcoholism
• prior h/o DVT or hypercoagulability
• concurrent medications that significantly affect cytochrome P450 3A4
• breast feeding or pregnancy

Where it is running

• Yale-New Haven Hospital — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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