Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents

Completed · Phase 1 · Has a placebo group

Conditions studied: Tobacco Use Disorder

In brief

Nicotine is one of the most widely abused substances in the United States. Nicotine replacement therapy (NRT) is currently an effective treatment for nicotine dependence; however, even with NRT most people fail at quitting smoking after their first attempt. Modafinil is a promising drug that may be useful in treating nicotine dependent individuals. The purpose of this study is to evaluate the safety of the combination of modafinil and NRT in treating nicotine dependent adolescent smokers.

Key facts

Study ID

NCT00258479

Run by

Catherine Martin, MD

People needed

24

Starts

2003-06-01

Expected to finish

2011-12-01

Last updated by the study team

2017-05-11

Who can join

Age: 16 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Smokes 10 or more cigarettes per day

You may not qualify if…

• Current use of any medication for a psychiatric disorder
• Positive drug screen test
• Uses smokeless tobacco

Where it is running

• University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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