Baclofen Effects on Smoking Urge and Withdrawal

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Nicotine Use Disorder, Nicotine Dependence, Smoking, Tobacco Use Disorder

In brief

The purpose of this study is to determine whether baclofen is effective in reducing smoking urge, withdrawal, and reinforcement in moderate to heavy cigarette smokers.

Key facts

Study ID

NCT00257894

Run by

VA Office of Research and Development

People needed

41

Starts

2005-12-01

Expected to finish

2008-12-01

Last updated by the study team

2015-11-04

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Smoke at least 10 cigarettes per day for at least 6 months and considering quitting smoking in the next 6 months-

You may not qualify if…

• Planning to attempt smoking cessation within the next 4 months
• Weight less than 110 lbs. or above 220 lbs.
• Use of tobacco products other than cigarettes in the previous month.
• History of: Kidney disease, uncontrolled conditions (e.g., cardiac disease, pulmonary disease, diabetes, hypertension) Neurological disease (including stroke, mini-stroke, brain injury, Alzheimers Disease, encephalitis, meningitis, seizure disorder),Phenylketonuria Schizophrenia, Schizoaffective Disorder, Paranoid Disorder, or Schizotypal Disorder.
• Current alcohol and/or drug use disorder as indicated by a screening questionnaire, past treatment for alcohol or substance use problems unless in remission(clean and sober for past year or more) or intention to seek treatment in the next 6 months for alcohol or substance use problems.
• For women: Pregnancy, nursing, not using a reliable form of birth control.
• Allergy to baclofen, Lioresal, or Kemstro.
• Taking the following medications: antidepressants(excluding selective serotonin reuptake inhibitors), bupropion, phenothiazines, antihistamines, sedative/hypnotics, benzodiazepines, alpha blockers, beta blockers.
• Lives with someone enrolled in the study.

Where it is running

• VA Medical Center, Providence — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.