Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease

Completed · Phase 2 · Has a placebo group

Conditions studied: Alzheimer's Disease

In brief

The purpose of this study is to determine in a 12-week treatment study if MEM 1003 is a safe and effective treatment for patients with mild to moderate Alzheimer's disease.

Key facts

Study ID

NCT00257673

Run by

Memory Pharmaceuticals

People needed

183

Starts

2005-11-01

Expected to finish

2007-10-01

Last updated by the study team

2008-05-06

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• standardized MMSE Score of 10 to 24 points
• diagnosis of probable Alzheimer's disease
• magnetic resonance imaging or computed tomography examination compatible with AD
• modified Hachinski Ischemia Score of less than or equal to 4
• currently receiving no AD therapy or currently receiving donepezil, rivastigmine, or galantamine

You may not qualify if…

• head injury associated with cognitive impairment
• history of vascular dementia stroke, transient cerebral ischemic episodes, major depression, major psychotic disorder, or symptomatic postural hypotension
• treatment for Alzheimer's disease other than donepezil, rivastigmine, or galantamine; tacrine is not permitted in the last 30 days or memantine in the last 90 days
• treatment with calcium channel blockers or any investigational medications within the prior 30 days

Where it is running

• Study site — Mesa, Arizona, United States
• Study site — Phoenix, Arizona, United States
• Study site — Sun City, Arizona, United States
• Study site — El Centro, California, United States
• Study site — Riverside, California, United States
• Study site — San Francisco, California, United States
• Study site — Torrence, California, United States
• Study site — Hamden, Connecticut, United States
• Study site — Washington D.C., District of Columbia, United States
• Study site — Brooksville, Florida, United States
• Study site — Chiefland, Florida, United States
• Study site — Coral Springs, Florida, United States
• Study site — Deerfield Beach, Florida, United States
• Study site — Delray Beach, Florida, United States
• Study site — Hallandale, Florida, United States
• Study site — Hialeah, Florida, United States
• Study site — Miami, Florida, United States
• Study site — Miami, Florida, United States
• Study site — Miami, Florida, United States
• Study site — Plantation, Florida, United States
• Study site — Port Charlotte, Florida, United States
• Study site — Sarasota, Florida, United States
• Study site — St. Petersburg, Florida, United States
• Study site — Sunrise, Florida, United States
• Study site — Northport, Alabama, United States

Full record on ClinicalTrials.gov

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