Fatty Acid Binding Protein 2 (FABP2) Ancillary Proposal
Completed
Conditions studied: Type 2 Diabetes Mellitus
In brief
TITLE: CSP 465-C, Fatty Acid Binding protein 2 (FABP2) ancillary proposal to CSP# 465 Glycemic Control and Complications in Diabetes Mellitus Type 2. Angeliki Georgopoulos, M.D. Carlos Abraira M.D. William Duckworth M.D. Fatty acid binding protein 2 (FABP2) is involved in the transport of long chain fatty acids across the intestinal epithelium. A common (40-45%) polymorphism of FABP2 gene (codon 54 Threonine for Alanine) results in increased intestinal fatty acid absorption and triglyceride secretion (Baier et al J Clin Invest 95:1281-87, 1995; Baier et al J Biol Chem 271: 10892-10896,1996). We have found (JCEM 85:3155-60, 2000) that in patients with type 2 diabetes, the codon 54 polymorphism of the FABP2 results in fasting and postprandial hypertriglyceridemia. Since hypertriglyceridemia is a risk factor for atherosclerosis in type 2 diabetes and it is part of the insulin resistance syndrome, the objective of this ancillary study would be to screen the participants of the CSP# 465 study for the polymorphism and assess a) whether those carrying the polymorphism respond differently to the various treatment modalities and b) whether they develop more cardiovascular events compared to the ones lacking the polymorphism. There is one study that suggests an association of the polymorphism with a history of parental stroke (JCEM 85:2801-4, 2000). The only additional request from the study participants will be to agree to the collection of a blood sample to be used for DNA isolation and screening for the polymorphism. No additional funds are requested. If this polymorphism proves to be a predictor of either the response to a specific treatment modality or of the risk to macro-vascular complications, it will be very easy to screen for it and target our treatment modalities appropriately.
Key facts
- Study ID
- NCT00256633
- Run by
- US Department of Veterans Affairs
- People needed
- 874
- Starts
- 2007-04-01
- Expected to finish
- 2008-05-01
- Last updated by the study team
- 2014-05-23
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with type 2 DM who are no longer responsive to maximum dose of one or more oral agents.
You may not qualify if…
- Patients not registered in the VADT.
Where it is running
- Carl T. Hayden VA Medical Center — Phoenix, Arizona, United States
- Southern Arizona VA Health Care System, Tucson — Tucson, Arizona, United States
- VA Central California Health Care System, Fresno — Fresno, California, United States
- VA San Diego Healthcare System, San Diego — San Diego, California, United States
- VA Medical Center, Miami — Miami, Florida, United States
- Edward Hines, Jr. VA Hospital — Hines, Illinois, United States
- Richard Roudebush VA Medical Center, Indianapolis — Indianapolis, Indiana, United States
- VA Medical Center, Lexington — Lexington, Kentucky, United States
- VA Medical Center, Minneapolis — Minneapolis, Minnesota, United States
- VA Medical Center, Omaha — Omaha, Nebraska, United States
- VA New Jersey Health Care System, East Orange — East Orange, New Jersey, United States
- VA Pittsburgh Health Care System — Pittsburgh, Pennsylvania, United States
- VA Medical Center — Nashville, Tennessee, United States
- VA South Texas Health Care System, San Antonio — San Antonio, Texas, United States
- VA Medical Center, Salem VA — Salem, Virginia, United States
- VA Medical Center, San Juan — San Juan, Puerto Rico
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.