Resveratrol for Patients With Colon Cancer
Completed · Phase 1
Conditions studied: Colon Cancer, Cancer
In brief
Resveratrol is purported to possess cancer preventive activity, especially for colon cancer, though its mechanisms of action are not well defined. Resveratrol is found in the skin of grapes and has anti-oxidative and pro-apoptotic effects on cancer cell lines in vitro. The main dietary sources of resveratrol are grapes, grape products, and red wine, and small amounts may be found in mulberries. A prior report and compelling preliminary data from our laboratory suggest that resveratrol modulates Wnt signaling, a signaling pathway which is activated in over 85% of colon cancers. In this proposal, studies were performed to define the actions of resveratrol on the Wnt signaling pathway in a clinical trial in which patients with colon cancer received treatment with Resveratrol, and correlative laboratory studies examined its effects directly on colon cancer and normal colonic mucosa. These studies provided data on the mechanisms of resveratrol action and provided a foundation for future prevention trials, correlative studies and therapeutic clinical research with this agent.
Key facts
- Study ID
- NCT00256334
- Run by
- University of California, Irvine
- People needed
- 11
- Starts
- 2005-07-01
- Expected to finish
- 2009-04-01
- Last updated by the study team
- 2014-06-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients diagnosed with colon cancer by colonoscopic biopsy and tissue obtained under UCI04-05.
- Patients with a plan for surgical resection at UCIMC within 2-4 weeks of enrollment.
You may not qualify if…
- Surgical resection to be performed at a facility other than UCIMC.
- Patients under 18 years of age.
Where it is running
- Chao Family Comprehensive Cancer Center — Orange, California, United States
Full record on ClinicalTrials.gov
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