Effects of Smoked Marijuana on Neuropathic Pain

Completed · Phase 1/Phase 2

Conditions studied: Neuropathic Pain

In brief

To determine if smoking marijuana will reduce neuropathic pain without causing too much drowsiness or feeling "too dopey".

Key facts

Study ID

NCT00254761

Run by

Center for Medicinal Cannabis Research

People needed

28

Starts

2003-11-01

Expected to finish

2006-02-01

Last updated by the study team

2008-02-28

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Able to understand English
• Age greater than 18 and less than 70
• VAS greater than 3/10
• History of previous marijuana use (i.e., avoidance of marijuana naive subjects)
• Negative urine drug screening test
• Nerve Injury a.k.a. Complex Regional Pain Syndrome Type II OR
• Complex Regional Pain Syndrome Type I OR
• Neuropathic pain due to confirmed bilateral distal peripheral neuropathy associated with Diabetes I or II, focal nerve injury, postherpetic neuralgia, spinal cord injury with incomplete myelopathy, central pain following a stroke or focal brain lesion, or clinical definite multiple sclerosis of at least 3 months duration.

You may not qualify if…

• Presence of another painful condition of greater severity than the neuropathic pain condition which is being studied
• Unstable Type 1 or 2 diabetes defined as blood glucose more than 156 mg/dl
• For diabetic subjects maintained on insulin with a stable blood glucose more than 156 mg/dl, a hemoglobin A1C level of more than 0.11 (normal range, 0.048-0.067)
• History of traumatic brain injury
• History of schizophrenia or a past or current history of a serious psychiatric disorder that is currently not well controlled with medications
• Uncontrolled medical condition - coronary artery disease, hypertension, cerebrovascular disease, asthma, TB, COPD, opportunistic infection, malignancy requiring active treatment
• Active substance abuse (alcohol or injection drugs)
• Current use of marijuana (within 30 days of randomization) as determined by urine screening

Where it is running

• UC Davis Medical Center — Sacramento, California, United States

Full record on ClinicalTrials.gov

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