Metabolic Effects of Chemical Interactions in Toxicity

Completed · Not applicable

Conditions studied: Oxidative Stress

In brief

This pilot study tests the feasibility of using GSH redox state and high resolution proton NMR spectroscopy (1H-NMR) to detect metabolic changes due to acetominophen and sulfur amino acid deficiency. Our central hypothesis is that the a 2-day sulfur amino acid deficiency will alter acetominophen metabolism, acetominophen will affect sulfur amino acid homeostasis, and the treatments together will alter the global metabolic profile, as measured by 1H-NMR spectroscopy.

Key facts

Study ID

NCT00253773

Run by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

People needed

15

Starts

2005-01-01

Expected to finish

2007-11-01

Last updated by the study team

2010-01-13

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy volunteers males and females

You may not qualify if…

• acute/chronic illnesses age less than 18 and greater than 40 pregnancy

Where it is running

• Emory University Hospital — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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