Metabolic Analysis in Human Sulfur Amino Acid Deficiency

Completed · Not applicable

Conditions studied: Oxidative Stress, Diabetes, Heart Diseases

In brief

Varied food intake, disease, and genetic differences result in complex diet-health interactions. In principle, information-rich metabolic analyses combined with bioinformatic tools provide an approach to explore these interactions. This project is a feasibility study of the use of high-resolution 1H-nuclear magnetic resonance (NMR) to study metabolic perturbations induced by a deficiency in sulfur amino acids (SAA). The investigators will 1) test the hypothesis that deficient dietary intake of SAA in humans results in oxidation of reduced glutathione (GSH)/oxidized glutathione (GSSG) redox and 2) determine whether 1H-NMR of blood and urine detects metabolic changes due to SAA deficiency.

Key facts

Study ID

NCT00253760

Run by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

People needed

15

Starts

2004-02-01

Expected to finish

2007-02-01

Last updated by the study team

2010-03-18

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normal weight
• Males or females

You may not qualify if…

• Smokers
• Pregnancy
• Chronic illness other than hypertension
• Age less than 18 and greater than 40 years

Where it is running

• Emory University Hospital — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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