Smoking Cessation for Adults With Attention Deficit Hyperactivity Disorder (ADHD)

Completed · Phase 3 · Has a placebo group

Conditions studied: ADHD, Smoking

In brief

The objective of this study is to evaluate whether Osmotic-Release Methylphenidate (OROS MPH), relative to placebo, increases the effectiveness of standard smoking treatment (i.e., nicotine patch and individual smoking cessation counseling) in obtaining prolonged abstinence for smokers with Attention Deficit Hyperactivity Disorder (ADHD).

Key facts

Study ID

NCT00253747

Run by

University of Cincinnati

People needed

255

Starts

2005-11-01

Expected to finish

2008-03-01

Last updated by the study team

2012-09-17

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of ADHD2
• Smoked cigarettes for at least 3 months
• Currently smoking > 10 cigarettes/day
• Have an interest in quitting
• Negative urine screen for cocaine, methamphetamine, opiates, benzodiazepines, and marijuana

You may not qualify if…

• Have a clinical diagnosis for current abuse or dependence for any psychoactive substance other than nicotine, depression, or anxiety; or a life-time clinical diagnosis of psychosis or bipolar disorder
• Allergic to OROS-MPH
• Pregnant or breastfeeding
• Abnormal electrocardiogram (ECG)
• Taking a Monoamine Oxidase (MAO) Inhibitor
• Taking any medication used for treating either ADHD or smoking
• Use of tobacco products other than cigarettes in the past week
• Blood pressure readings greater than 135/85 and/or a heart rate more than 90 beats per minute on three consecutive clinic visits

Where it is running

• Massachusetts General Hospital — Cambridge, Massachusetts, United States
• Mayo Clinic Nicotine Research Program — Rochester, Minnesota, United States
• VA New York Harbor Healthcare System — New York, New York, United States
• New York State Psychiatric Institute - Smoking Cessation Program — New York, New York, United States
• Maryhaven, Inc. — Columbus, Ohio, United States
• Kaiser Permanente (Center for Health Research) — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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