Alterations in Protein Synthesis Rates of Burn Patients Measured Over Time Using PET Scans

Status unconfirmed

Conditions studied: Burn

In brief

Our specific aim is to gain an understanding of protein synthesis rates in burn patients at various times during their injury and recovery by using PET scans. This will be compared with healthy volunteer controls. We hope this will help optimize nutrition and care regimens for future burn patients.

Key facts

Study ID

NCT00253279

Run by

Massachusetts General Hospital

People needed

64

Starts

2009-11-01

Expected to finish

2010-01-01

Last updated by the study team

2009-08-13

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• FOR HEALTHY VOLUNTEERS
• Healthy males and females 18-70 years of age.
• Laboratory results within MGH-accepted normal range.
• Within 20% of the ideal weight for their height.
• Supine and standing blood pressure within the range of 110/60 to 150/90 mm Hg
• Heart rate within the range of 46-90 beats/minute after 5 minutes of rest.
• Subjects <40 years old with HCT >=24, age 40-60 with HCT >=27, age 60-70 with HCT >=30.
• FOR BURN SUBJECTS:
• Inclusion Criteria:
• Burn Injury of >=5 % TBSA from any cause.
• 18 -70 years of age
• Stable hemodynamic and cardiopulmonary states as judged by the attending surgeons in the burn unit.
• Patient who is capable of giving full informed consent.

You may not qualify if…

• FOR HEALTHY SUBJECTS Clinical evidence of physical or mental disease.
• Clinically significant abnormality of the laboratory tests.
• Known drug or alcohol dependence.
• History of drug allergy
• Taking standard prescription drugs within two weeks or investigational drugs within four weeks prior to the PET scan
• Diabetes mellitus and other metabolic endocrine disorders Pregnant or lactating
• FOR BURN SUBJECTS:
• Pregnant or lactating females

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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